Colon Motility in The Rats After Long-Term Treatment of Omeprazole and Pantoprazole

Abstract

The aim of the study was to investigate the consequences of long-term use of proton pump inhibitors (PPIs) on colon motility in the rats. The study was done on 30 male albino rats which were divided into 3 groups. As a control were rats, which were injected 0.2 ml of water for 28 days intraperitoneally (i.p.). The rats of second group received omeprazole (“Sigma Aldrich”, USA) and the rats of third group – pantoprazole (Ulsepan, “World Medicine”, Great Britain) in dose 14 mg/kg i.p. once a day for 28 days. One day after the last administration of drugs, the spontaneous and stimulated by carbachol colon motility was recorded by the balloongraphic method. Gastrin concentration in blood serum was determined by the radioimmune method. Long-term use of omeprazole and pantoprazole leads to diminishing of spontaneous and stimulated by carbachol colon motility and increase of gastrin concentration in blood serum by 3,1-fold and 1,6-fold consequently. We concluded that suppression of colon motility after long-term use of PPIs is the result of hypergastrinemia evoked by diminishing of gastric acid secretion. The effect of omeprazole on colon motility was expressed more strongly which we associate with its greater effect on the growth of gastrin concentration