INFLUENCE OF OPEFERA ON THE COLON MOTILITY OF RATS IN THE CONDITIONS OF PROLONGED GASTRIC JUICE HYPOACIDITY

Abstract

Introduction: Gastric hypohlorhydria is the result of inflammatory process in the intestine caused by dysbiosis. Multiprobiotics significantly improve the colon’s motility. Not only probiotics, but also synbiotics are used to eliminate dysbiosis The aim of the work was to study the effect of Opefera on spontaneous and stimulated contractile activity of the colon in rats. Materials and methods:The studies were carried out on 30 white rats, divided into 3 groups. The rats of group I served as controls; they daily received water for injections for 28 days. Group II rats received omeprazole daily for 28 days and rectally - water. Rats of group III were given omeprazole and Opefera simultaneously during 28 days. On the 29th day the colon motility was examined by the balonography method [13]. To do this, the “Jaguar” automated unit was used. For statistic data processing, Student’s t-criterion for independent samples was applied. Results: In the group of rats, which received omeprazole and Opefera simultaneously during 28 days, the index of motor activity increased compared to the group of rats given omeprazole only. Thus, application of the Opefera drug enhances the spontaneous and stimulated motility of the colon, suppressed by prolonged hypochlorhydria of gastric juice. Conclusion: The Opefera drug stimulates spontaneous and stimulated motility of the colon, suppressed by prolonged hypochlorhydria of gastric juice. Opefera application is expedient in patients with prolonged hypochlorhydria of various genesis to normalize the colon contractile activity.