Gastric Motor Activity After Prolonged Administration Of Omeprazole And Pantoprazole

Abstract

The aim of the study was to investigate the effects of prolonged treatment of proton pump blockers on gastric motility in the rats and compare changes with control group rats. The study of gastric motility was done on white non-linear male rats with use balloon graphic method. Farther we investigated Mg2+,Ca2+ - ATPase and K+ (EGTA)-ATPase activity of actomyosin of smooth gastric muscles. After 28 days of administration of omeprazole and pantoprazole, the frequency of spontaneous contractions in the stomach did not change, and the amplitude of spontaneous contractions decreased by 79.7% (p 0,05). Long-term inhibition of gastric acid secretion by proton pump blockers leads to decrease of spontaneous and stimulated gastric motility, which manifested in the changing of functional state of the actomyosin smooth muscles of the stomach. At the same time, the effect of pantoprazole was weaker than that of omeprazole. Therefore, for long-term administration of proton pump blockers, for example, in chronic reflux esophagitis, it is advisable to appoint pantoprazole.